San Francisco, March 1909. Our story continues approximately 24 hours after the events of Episode 1. Simon Viernik, otherwise known as The Amazing Viernik (Fred Backus), has been forced by the San Francisco Police Department to assist the eccentric Leslie Caldwell (Matt Gray), a Detective of the Supernatural. The two men search the streets of San Francisco for the vampire that supposedly escaped from Viernik's cage and killed a man. Caldwell uses his profound and somewhat bizarre detective skills to track the vampire and concludes it must be hiding in the home of a mysterious gentleman (Bryan Enk).

The Amazing Viernik distracts the mysterious gentleman, who we will later discover is named Cyrus Pierce, with magic tricks (mostly involving making Pierce's dinner "disappear" into his own mouth) as Caldwell searches the wine cellar for the vampire. He is soon caught by Pierce, who throws both Caldwell and Viernik out of his home, furious at their trespassing and aghast at their absurd investigation, finally asking them both a question that seems to contradict Caldwell's entire hunt: "Why would a vampire dispose of a body?"

Caldwell and Viernik go to a nearby pub and ponder this question that implies that the animal they are hunting seems to work on conscious decision-making and cunning rather than instinct. Their solitude is interrupted by John Sullivan (director Danny Bowes), a boisterous fireman who encourages Viernik to join him in a toast to "stinkin' Tom O'Malley," a colleague of Sullivan's who apparently died in a fire that morning. The drunken Sullivan also tells Viernik some personal details about Caldwell - Sullivan calls Caldwell a "newspaper boy," accusing him of being unable to do "real" detective work, so media tycoon William Randolph Hearst turned him into a "Detective of the Supernatural," going after vampires and werewolves and other things that don't exist - but do sell newspapers.

Sullivan also goes a little too far, reminding Caldwell that he was responsible for the death of a little girl, an incident that is only ever referred to as "that thing happened at Baker Beach." The final straw for Caldwell is when Sullivan says, "To top it off, his old lady's completely batshit." Just as a real fight is about to break out between Caldwell and Sullivan, one of the policemen we saw in Episode 1 (Bryan Enk) arrives at the pub, calming the situation and telling Caldwell that there's "trouble with your missus again."

Caldwell and Viernik follow the policeman to the home of Madame Petrovsky (Hope Cartelli), an exotic medium. Her living room has been trashed, apparently by the beautiful, silent, feeble-looking woman in the corner, Ethel Caldwell (Dina Rose Rivera). Petrovsky is furious and demands that Ethel be arrested. The policeman escorts Ethel out of the house as Caldwell threatens to expose Madame Petrovsky and all of her con artist peers. He gives her monetary compensation for the damages and warns her to never speak a word of this to anyone.

On the street, Viernik tries to cheer the troubled Ethel. We learn that Ethel has done this before; she has been going from medium to medium, spiritualist to spiritualist, trying to contact a deceased man whose name she doesn't reveal. When Caldwell joins them and calls her "Ethel," she reprimands him, telling her that her real name is Etta Place. Caldwell tries to comfort her and she leaves by herself, calmer but still melancholy, haunted by a dead man who she seems to love more than her protective husband.

Viernik and Caldwell go to the morgue, where William 'Cadaver' Cavender (Jeff Lewonczyk) shows them the body of the vampire's victim. Cavender points out two little holes on the victim's neck, which is where he believes the body's entire blood supply was lost. Cavender also points out the victim's elaborate tattoo work: "IRAQ - Desert Fox - 2003." Caldwell sighs and says this is indeed the kind of "fruity case" that he's become known for. Cavender tells Caldwell that he has a bad feeling about all of this - Caldwell tells him to get some sleep and that he and Viernik will lock up the morgue.

After Cavender leaves, Caldwell tells Viernik, who has refused to look at the body, that he knew the victim, if only in passing. The victim was apparently a Pinkerton detective, like Caldwell. Viernik finally agrees to look at the body - when he does, he retreats in shock. He tells Caldwell that he knows the victim as well - he is the man who Mister E brought into the world. He is the man from the Great Switcheroo!